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KMID : 0605720160220010013
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Journal of the Korean Society of Biological Therapies in Psychiatry
2016 Volume.22 No. 1 p.13 ~ p.26
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Relation between Geriatric Depression and Alzheimer`s Disease - Based on Amyloid Theory
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Kim Hye-Guem
Cheon Eun-Jin
Koo Bon-Hoon
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Abstract
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There are many overlapping symptoms between geriatric depression and dementia, particularly Alzheimer type. Patients with geriatric depression have cognitive impairment resulting from attention deficit, rigidity of thinking, processing speed, and so on. The cognitive impairment caused by depression does not completely disappear even after cured depression. Also, patients with Alzheimer’s disease(AD) often have comorbid depressive symptoms including apathy. And of patients with minor cognitive impairment(MCI), patients with neuropsychiatric symptoms including depression, anxiety, converted to AD more often. Numerous studies have indicated that lifetime depression is associated with developing AD. Recently, amyloid PET is a available measure that demonstrate the relation between depression and AD. In conclusion, when the patient with geriatric depression also have cognitive impairment, we should carefully follow up the patients whether develop AD or not, and we can check the amyloid PET to make further clinical decision and plan.
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KEYWORD
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Geriatric depression, Alzheimer’s dementia, Minor cognitive impairment, Amyloid PET
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